Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice

The apoptotic cysteine protease caspase-2 has been shown to suppress tumourigenesis in mice and its reduced expression correlates with poor prognosis in some human malignancies. Caspase-2-deficient mice develop normally but show ageing-related traits and, when challenged by oncogenic stimuli or cert...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Dawar, Swati, Shahrin, Nur Hezrin, Sladojevic, Nikolina, D'Andrea, Richard J, Dorstyn, Loretta, Hiwase, Devendra K, Kumar, Sharad
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260989/
https://ncbi.nlm.nih.gov/pubmed/27906175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.406
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