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N-Heterocyclic Carbene Gold(I) Complexes Conjugated to a Leukemia Specific DNA-Aptamer for Targeted Drug Delivery

This report describes the synthesis and characterization of novel N-heterocyclic carbene (NHC) gold(I) complexes and their bioconjugation to the CCRF-CEM leukemia specific aptamer sgc8c. Confirmation of successful bioconjugation was achieved by using fluorescent tags on both the NHC-Au(I) complex an...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Niu, Weijia, Chen, Xigao, Tan, Weihong, Veige, Adam S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260866/
https://ncbi.nlm.nih.gov/pubmed/27311814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201602702
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