Acetylation enhances TET2 function in protecting against abnormal DNA methylation during oxidative stress

TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role linked to DNA damage from oxidative stress (OS) k...

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Udgivet i:Mol Cell
Main Authors: Zhang, Yang W., Wang, Zhihong, Xie, Wenbing, Cai, Yi, Xia, Limin, Easwaran, Hariharan, Luo, Jianjun, Chiu Yen, Ray-Whay, Li, Yana, Baylin, Stephen B.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260804/
https://ncbi.nlm.nih.gov/pubmed/28107650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.12.013
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