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Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress, and apoptosis

BACKGROUND: Maternal type 1 and 2 diabetes mellitus are strongly associated with high rates of severe structural birth defects, including congenital heart defects. Studies in type 1 diabetic embryopathy animal models have demonstrated that cellular stress-induced apoptosis mediates the teratogenicit...

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Bibliografiske detaljer
Udgivet i:Am J Obstet Gynecol
Main Authors: Wu, Yanqing, Reece, E. Albert, Zhong, Jianxiang, Dong, Daoyin, Shen, Wei-Bin, Harman, Christopher R., Yang, Peixin
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260663/
https://ncbi.nlm.nih.gov/pubmed/27038779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2016.03.036
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