Ask1 Gene Deletion Blocks Maternal Diabetes–Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome

Apoptosis signal–regulating kinase 1 (ASK1) is activated by various stresses. The link between ASK1 activation and endoplasmic reticulum (ER) stress, two causal events in diabetic embryopathy, has not been determined. We sought to investigate whether ASK1 is involved in the unfolded protein response...

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Vydáno v:Diabetes
Hlavní autoři: Wang, Fang, Wu, Yanqing, Gu, Hui, Reece, E. Albert, Fang, Shengyun, Gabbay-Benziv, Rinat, Aberdeen, Graham, Yang, Peixin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2015
Témata:
Pathophysiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338585/
https://ncbi.nlm.nih.gov/pubmed/25249581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0409
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