A role for proteinase-activated receptor–1 in inflammatory bowel diseases

Proteinase-activated receptor–1 (PAR(1)), a G protein–coupled receptor activated by thrombin, is highly expressed in different cell types of the gastrointestinal tract. The activity of thrombin and of other proteinases is significantly increased in the colon of inflammatory bowel disease (IBD) patie...

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Hauptverfasser: Vergnolle, Nathalie, Cellars, Laurie, Mencarelli, Andrea, Rizzo, Giovanni, Swaminathan, Sunita, Beck, Paul, Steinhoff, Martin, Andrade-Gordon, Patricia, Bunnett, Nigel W., Hollenberg, Morley D., Wallace, John L., Cirino, Giuseppe, Fiorucci, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC526028/
https://ncbi.nlm.nih.gov/pubmed/15545995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421689
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