Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism

1. Thrombin, generated in the circulation during injury, cleaves proteinase-activated receptor 1 (PAR1) to stimulate plasma extravasation and granulocyte infiltration. However, the mechanism of thrombin-induced inflammation in intact tissues is unknown. We hypothesized that thrombin cleaves PAR1 on...

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Detalhes bibliográficos
Main Authors: Garavilla, Lawrence de, Vergnolle, Nathalie, Young, Steven H, Ennes, Helena, Steinhoff, Martin, Ossovskaya, Valeria S, D'Andrea, Michael R, Mayer, Emeran A, Wallace, John L, Hollenberg, Morley D, Andrade-Gordon, Patricia, Bunnett, Nigel W
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572861/
https://ncbi.nlm.nih.gov/pubmed/11487506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704152
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