A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk

Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. This phenomenon allows for selecting a limited number of SNPs from GWAS repositories for large-scale studies investigating s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Elands, Rachel J. J., Simons, Colinda C. J. M., Riemenschneider, Mona, Isaacs, Aaron, Schouten, Leo J., Verhage, Bas A., Van Steen, Kristel, Godschalk, Roger W. L., van den Brandt, Piet A., Stoll, Monika, Weijenberg, Matty P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259777/
https://ncbi.nlm.nih.gov/pubmed/28117334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41034
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