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Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors

The salivary glands of animals have great potential to act as powerful bioreactors to produce human therapeutic proteins. Human nerve growth factor (hNGF) is an important pharmaceutical protein that is clinically effective in the treatment of many human neuronal and non-neuronal diseases. In this st...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Zeng, Fang, Li, Zicong, Zhu, Qingchun, Dong, Rui, Zhao, Chengcheng, Li, Guoling, Li, Guo, Gao, Wenchao, Jiang, Gelong, Zheng, Enqin, Cai, Gengyuan, Moisyadi, Stefan, Urschitz, Johann, Yang, Huaqiang, Liu, Dewu, Wu, Zhenfang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259756/
https://ncbi.nlm.nih.gov/pubmed/28117418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41270
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