Production of functional human nerve growth factor from the saliva of transgenic mice by using salivary glands as bioreactors

The salivary glands of animals have great potential to act as powerful bioreactors to produce human therapeutic proteins. Human nerve growth factor (hNGF) is an important pharmaceutical protein that is clinically effective in the treatment of many human neuronal and non-neuronal diseases. In this st...

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Vydáno v:Sci Rep
Hlavní autoři: Zeng, Fang, Li, Zicong, Zhu, Qingchun, Dong, Rui, Zhao, Chengcheng, Li, Guoling, Li, Guo, Gao, Wenchao, Jiang, Gelong, Zheng, Enqin, Cai, Gengyuan, Moisyadi, Stefan, Urschitz, Johann, Yang, Huaqiang, Liu, Dewu, Wu, Zhenfang
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259756/
https://ncbi.nlm.nih.gov/pubmed/28117418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41270
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