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Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC525739/ https://ncbi.nlm.nih.gov/pubmed/15545994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421753 |
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