Polycystin 1 is required for the structural integrity of blood vessels

Autosomal dominant polycystic kidney disease (ADPKD), often caused by mutations in the PKD1 gene, is associated with life-threatening vascular abnormalities that are commonly attributed to the frequent occurrence of hypertension. A previously reported targeted mutation of the mouse homologue of PKD1...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kim, Keetae, Drummond, Iain, Ibraghimov-Beskrovnaya, Oxana, Klinger, Katherine, Arnaout, M. Amin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26504/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677526/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040550097
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