Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a...

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Główni autorzy: Chauvet, Veronique, Tian, Xin, Husson, Herve, Grimm, David H., Wang, Tong, Hieseberger, Thomas, Igarashi, Peter, Bennett, Anton M., Ibraghimov-Beskrovnaya, Oxana, Somlo, Stefan, Caplan, Michael J.
Format: Artigo
Język:Inglês
Wydane: American Society for Clinical Investigation 2004
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC525739/
https://ncbi.nlm.nih.gov/pubmed/15545994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421753
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