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Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes
A paradox in monoclonal antibody (mAb) therapy is that despite the well-documented tolerogenic properties of deaggregated IgG, most therapeutic IgG mAb induce anti-mAb responses. To analyze CD4 T cell reactions against IgG in various physical states, we developed an adoptive transfer model using CD4...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5256993/ https://ncbi.nlm.nih.gov/pubmed/28114383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170556 |
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