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Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE

Serum IgG anti-nuclear antibodies (ANA) directed to complexes of DNA and histones are a hallmark of systemic lupus erythematosus (SLE) and reflect a failure in lymphocyte self-tolerance. A prior study utilizing spontaneously autoimmune B6.Nba2 mice deficient in terminal deoxynucleotidyl transferase...

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Bibliografiska uppgifter
I publikationen:J Autoimmun
Huvudupphovsmän: Detanico, Thiago, Guo, Wenzhong, Wysocki, Lawrence J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492439/
https://ncbi.nlm.nih.gov/pubmed/25634361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.01.006
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