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Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity
Systemic lupus erythematosus (SLE) is characterized by high-avidity IgG antinuclear antibodies (ANAs) that are almost certainly products of T cell–dependent immune responses. Whether critical amino acids in the third complementarity-determining region (CDR3) of the ANA originate from V(D)J recombina...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947070/ https://ncbi.nlm.nih.gov/pubmed/20805563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092712 |
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