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Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE
Serum IgG anti-nuclear antibodies (ANA) directed to complexes of DNA and histones are a hallmark of systemic lupus erythematosus (SLE) and reflect a failure in lymphocyte self-tolerance. A prior study utilizing spontaneously autoimmune B6.Nba2 mice deficient in terminal deoxynucleotidyl transferase...
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| Publicado no: | J Autoimmun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4492439/ https://ncbi.nlm.nih.gov/pubmed/25634361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.01.006 |
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