Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes

A paradox in monoclonal antibody (mAb) therapy is that despite the well-documented tolerogenic properties of deaggregated IgG, most therapeutic IgG mAb induce anti-mAb responses. To analyze CD4 T cell reactions against IgG in various physical states, we developed an adoptive transfer model using CD4...

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Pubblicato in:PLoS One
Autori principali: St. Clair, J. Benjamin, Detanico, Thiago, Aviszus, Katja, Kirchenbaum, Greg A., Christie, Merry, Carpenter, John F., Wysocki, Lawrence J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256993/
https://ncbi.nlm.nih.gov/pubmed/28114383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170556
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