Speedy A–Cdk2 binding mediates initial telomere–nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

Telomere attachment to the nuclear envelope (NE) is a prerequisite for chromosome movement during meiotic prophase I that is required for pairing of homologous chromosomes, synapsis, and homologous recombination. Here we show that Speedy A, a noncanonical activator of cyclin-dependent kinases (Cdks)...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Tu, Zhaowei, Bayazit, Mustafa Bilal, Liu, Hongbin, Zhang, Jingjing, Busayavalasa, Kiran, Risal, Sanjiv, Shao, Jingchen, Satyanarayana, Ande, Coppola, Vincenzo, Tessarollo, Lino, Singh, Meenakshi, Zheng, Chunwei, Han, Chunsheng, Chen, Zijiang, Kaldis, Philipp, Gustafsson, Jan-Åke, Liu, Kui
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255603/
https://ncbi.nlm.nih.gov/pubmed/28031483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618465114
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