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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
The activity of the SCF(skp2) E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a complex phenotype including changes in cell size and DNA content as well as severe proliferation de...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC525540/ https://ncbi.nlm.nih.gov/pubmed/15520280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.321004 |
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