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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

The activity of the SCF(skp2) E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a complex phenotype including changes in cell size and DNA content as well as severe proliferation de...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525540/
https://ncbi.nlm.nih.gov/pubmed/15520280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.321004
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