p27(Kip1) controls cytokinesis via the regulation of citron kinase activation

p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin–cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK–)) have increased incidence of tumor development as compared with wild-type and p27(–/–...

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Main Authors: Serres, Murielle P., Kossatz, Uta, Chi, Yong, Roberts, James M., Malek, Nisar P., Besson, Arnaud
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287231/
https://ncbi.nlm.nih.gov/pubmed/22293177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60376
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