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p27(Kip1) controls cytokinesis via the regulation of citron kinase activation
p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin–cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK–)) have increased incidence of tumor development as compared with wild-type and p27(–/–...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Clinical Investigation
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287231/ https://ncbi.nlm.nih.gov/pubmed/22293177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60376 |
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