Testing the importance of p27 degradation by the SCF(skp2) pathway in murine models of lung and colon cancer

Decreased expression of the CDK inhibitor p27(kip1) in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality. It is thought that decreased p27 expression in tumors is caused by increased proteas...

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Huvudupphovsmän: Timmerbeul, Inke, Garrett-Engele, Carrie M., Kossatz, Uta, Chen, Xueyan, Firpo, Eduardo, Grünwald, Viktor, Kamino, Kenji, Wilkens, Ludwig, Lehmann, Ulrich, Buer, Jan, Geffers, Robert, Kubicka, Stefan, Manns, Michael P., Porter, Peggy L., Roberts, James M., Malek, Nisar P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599904/
https://ncbi.nlm.nih.gov/pubmed/16966613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606316103
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