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Testing the importance of p27 degradation by the SCF(skp2) pathway in murine models of lung and colon cancer
Decreased expression of the CDK inhibitor p27(kip1) in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality. It is thought that decreased p27 expression in tumors is caused by increased proteas...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599904/ https://ncbi.nlm.nih.gov/pubmed/16966613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606316103 |
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