Testing the importance of p27 degradation by the SCF(skp2) pathway in murine models of lung and colon cancer

Decreased expression of the CDK inhibitor p27(kip1) in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality. It is thought that decreased p27 expression in tumors is caused by increased proteas...

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Detalles Bibliográficos
Main Authors: Timmerbeul, Inke, Garrett-Engele, Carrie M., Kossatz, Uta, Chen, Xueyan, Firpo, Eduardo, Grünwald, Viktor, Kamino, Kenji, Wilkens, Ludwig, Lehmann, Ulrich, Buer, Jan, Geffers, Robert, Kubicka, Stefan, Manns, Michael P., Porter, Peggy L., Roberts, James M., Malek, Nisar P.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599904/
https://ncbi.nlm.nih.gov/pubmed/16966613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606316103
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