Testing the importance of p27 degradation by the SCF(skp2) pathway in murine models of lung and colon cancer

Decreased expression of the CDK inhibitor p27(kip1) in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality. It is thought that decreased p27 expression in tumors is caused by increased proteas...

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Главные авторы: Timmerbeul, Inke, Garrett-Engele, Carrie M., Kossatz, Uta, Chen, Xueyan, Firpo, Eduardo, Grünwald, Viktor, Kamino, Kenji, Wilkens, Ludwig, Lehmann, Ulrich, Buer, Jan, Geffers, Robert, Kubicka, Stefan, Manns, Michael P., Porter, Peggy L., Roberts, James M., Malek, Nisar P.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599904/
https://ncbi.nlm.nih.gov/pubmed/16966613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606316103
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