Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.
Dihydrofolate reductase (DHFR; EC 1.5.1.3) is required in folate metabolism for the synthesis of purines, thymidine, and glycine. Although there have been several reports of induction of DHFR enzyme by methotrexate (MTX), a drug that competitively inhibits DHFR, there are no studies reported that ex...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1991
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1833762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8572 |
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