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Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors.

2,4-Diaminoquinazoline analogs of folate were assessed as antileishmanial agents and as dihydrofolate reductase inhibitors. Against Leishmania major in human macrophages in vitro, two compounds with tertiary amines attached directly to the quinazoline ring were remarkably active. The 50% effective d...

詳細記述

保存先:
書誌詳細
主要な著者: Berman, J D, King, M, Edwards, N
フォーマット: Artigo
言語:Inglês
出版事項: 1989
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC172777/
https://ncbi.nlm.nih.gov/pubmed/2610496
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