Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors.
2,4-Diaminoquinazoline analogs of folate were assessed as antileishmanial agents and as dihydrofolate reductase inhibitors. Against Leishmania major in human macrophages in vitro, two compounds with tertiary amines attached directly to the quinazoline ring were remarkably active. The 50% effective d...
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| Publicado no: | Antimicrob Agents Chemother |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1989
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172777/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2610496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.11.1860 |
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