Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.

Dihydrofolate reductase (DHFR; EC 1.5.1.3) is required in folate metabolism for the synthesis of purines, thymidine, and glycine. Although there have been several reports of induction of DHFR enzyme by methotrexate (MTX), a drug that competitively inhibits DHFR, there are no studies reported that ex...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Eastman, H B, Swick, A G, Schmitt, M C, Azizkhan, J C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1833762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8572
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