Inactivation of the Mgat1 Gene in Oocytes Impairs Oogenesis, but Embryos Lacking Complex and Hybrid N-Glycans Develop and Implant

Complex and hybrid N-glycans contain sugar residues that have been implicated in fertilization, compaction of the embryo, and implantation. Inactivation of the Mgat1 gene responsible for their synthesis is embryonic lethal, but homozygous mutant blastocysts are phenotypically normal due to the prese...

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Detalhes bibliográficos
Main Authors: Shi, Shaolin, Williams, Suzannah A., Seppo, Antti, Kurniawan, Henry, Chen, Wei, Ye, Zhengyi, Marth, Jamey D., Stanley, Pamela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525483/
https://ncbi.nlm.nih.gov/pubmed/15509794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.22.9920-9929.2004
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