Novel Mutations within the embB Gene in Ethambutol-Susceptible Clinical Isolates of Mycobacterium tuberculosis

Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATG→ATM substitution resulting in M306I, G406N, and the novel alteratio...

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Bibliographic Details
Main Authors: Lee, Ann S. G., Othman, Siti Noor Khadijah, Ho, Yu Min, Wong, Sin Yew
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC525425/
https://ncbi.nlm.nih.gov/pubmed/15504879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4447-4449.2004
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