The Severe Acute Respiratory Syndrome Coronavirus Nsp15 Protein Is an Endoribonuclease That Prefers Manganese as a Cofactor

Nonstructural protein 15 (Nsp15) of the severe acute respiratory syndrome coronavirus (SARS-CoV) produced in Escherichia coli has endoribonuclease activity that preferentially cleaved 5′ of uridylates of RNAs. Blocking either the 5′ or 3′ terminus did not affect cleavage. Double- and single-stranded...

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Bibliographic Details
Main Authors: Bhardwaj, Kanchan, Guarino, Linda, Kao, C. Cheng
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC525082/
https://ncbi.nlm.nih.gov/pubmed/15507608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12218-12224.2004
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