Immunogenicity and Protection Efficacy of Replication-Deficient Influenza A Viruses with Altered NS1 Genes

We explored the immunogenic properties of influenza A viruses with altered NS1 genes (NS1 mutant viruses). NS1 mutant viruses expressing NS1 proteins with an impaired RNA-binding function or insertion of a longer foreign sequence did not replicate in murine lungs but still were capable of inducing a...

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Bibliografiska uppgifter
Huvudupphovsmän: Ferko, Boris, Stasakova, Jana, Romanova, Julia, Kittel, Christian, Sereinig, Sabine, Katinger, Hermann, Egorov, Andrej
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Vaccines and Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC524997/
https://ncbi.nlm.nih.gov/pubmed/15542655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13037-13045.2004
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