Effects of Mutations in the G Tract of the Human Immunodeficiency Virus Type 1 Polypurine Tract on Virus Replication and RNase H Cleavage

The RNase H cleavages that generate and remove the polypurine tract (PPT) primer during retroviral reverse transcription must be specific in order to create a linear viral DNA that is suitable for integration. Lentiviruses contain a highly conserved sequence consisting of six guanine residues at the...

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Autores principales: Julias, John G., McWilliams, Mary Jane, Sarafianos, Stefan G., Alvord, W. Gregory, Arnold, Eddy, Hughes, Stephen H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC524982/
https://ncbi.nlm.nih.gov/pubmed/15542682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13315-13324.2004
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