Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease

Lung cellular senescence and inflammatory response are the key events in the pathogenesis of chronic obstructive pulmonary disease (COPD) when cigarette smoke (CS) is the main etiological factor. Telomere dysfunction is induced by either critical shortening or disruption of the shelterin complex, le...

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Publicat a:Am J Respir Cell Mol Biol
Autors principals: Ahmad, Tanveer, Sundar, Isaac K., Tormos, Ana M., Lerner, Chad A., Gerloff, Janice, Yao, Hongwei, Rahman, Irfan
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2017
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248966/
https://ncbi.nlm.nih.gov/pubmed/27559927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0198OC
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