Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema

Histone deacetylase 2 (HDAC2), a critical determinant of chromatin remodeling, is reduced as a consequence of oxidative stress-mediated DNA damage and impaired repair. Cigarette smoke (CS) exposure causes DNA damage and cellular senescence. However, no information is available on the role of HDAC2 i...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Sundar, Isaac K., Rashid, Kahkashan, Gerloff, Janice, Rangel-Moreno, Javier, Li, Dongmei, Rahman, Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103175/
https://ncbi.nlm.nih.gov/pubmed/29630406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701518R
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