Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

Cigarette smoke (CS)-induced cellular senescence is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). The molecular mechanism by which CS induces cellular senescence is unknown. Here, we show that CS stress (exposure of primary lung cells to CS extract 0.2–0.75% with a ha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:FASEB J
Prif Awduron: Ahmad, Tanveer, Sundar, Isaac K., Lerner, Chad A., Gerloff, Janice, Tormos, Ana M., Yao, Hongwei, Rahman, Irfan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Federation of American Societies for Experimental Biology 2015
Pynciau:
Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478793/
https://ncbi.nlm.nih.gov/pubmed/25792665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-268276
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