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P21-PARP-1 Pathway Is Involved in Cigarette Smoke-Induced Lung DNA Damage and Cellular Senescence
Persistent DNA damage triggers cellular senescence, which may play an important role in the pathogenesis of cigarette smoke (CS)-induced lung diseases. Both p21(CDKN1A) (p21) and poly(ADP-ribose) polymerase-1 (PARP-1) are involved in DNA damage and repair. However, the role of p21-PARP-1 axis in reg...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
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Public Library of Science
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3823706/ https://ncbi.nlm.nih.gov/pubmed/24244594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080007 |
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