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The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor β locus

The pre-T cell receptor (TCR) functions as a critical checkpoint during αβ T cell development. Signaling through the pre-TCR controls the differentiation of immature CD4(-)CD8(-)CD25(+)CD44(-) [double-negative (DN)3] thymocytes into CD4(+)CD8(+) double-positive (DP) cells through the CD4(-)CD8(-)CD2...

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Main Authors: Eyquem, Stéphanie, Chemin, Karine, Fasseu, Magali, Bories, Jean-Christophe
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC524847/
https://ncbi.nlm.nih.gov/pubmed/15496469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405546101
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