Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer

Clear cell renal cell carcinoma (CCRCC) is an incurable malignancy in advanced stages and needs newer therapeutic targets. Transcriptomic analysis of CCRCCs and matched microdissected renal tubular controls revealed overexpression of NOTCH ligands and receptors in tumor tissues. Examination of the T...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Bhagat, Tushar D., Zou, Yiyu, Huang, Shizheng, Park, Jihwan, Palmer, Matthew B., Hu, Caroline, Li, Weijuan, Shenoy, Niraj, Giricz, Orsolya, Choudhary, Gaurav, Yu, Yiting, Ko, Yi-An, Izquierdo, María C., Park, Ae Seo Deok, Vallumsetla, Nishanth, Laurence, Remi, Lopez, Robert, Suzuki, Masako, Pullman, James, Kaner, Justin, Gartrell, Benjamin, Hakimi, A. Ari, Greally, John M., Patel, Bharvin, Benhadji, Karim, Pradhan, Kith, Verma, Amit, Susztak, Katalin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247657/
https://ncbi.nlm.nih.gov/pubmed/27909050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745208
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