Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer

Clear cell renal cell carcinoma (CCRCC) is an incurable malignancy in advanced stages and needs newer therapeutic targets. Transcriptomic analysis of CCRCCs and matched microdissected renal tubular controls revealed overexpression of NOTCH ligands and receptors in tumor tissues. Examination of the T...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bhagat, Tushar D., Zou, Yiyu, Huang, Shizheng, Park, Jihwan, Palmer, Matthew B., Hu, Caroline, Li, Weijuan, Shenoy, Niraj, Giricz, Orsolya, Choudhary, Gaurav, Yu, Yiting, Ko, Yi-An, Izquierdo, María C., Park, Ae Seo Deok, Vallumsetla, Nishanth, Laurence, Remi, Lopez, Robert, Suzuki, Masako, Pullman, James, Kaner, Justin, Gartrell, Benjamin, Hakimi, A. Ari, Greally, John M., Patel, Bharvin, Benhadji, Karim, Pradhan, Kith, Verma, Amit, Susztak, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247657/
https://ncbi.nlm.nih.gov/pubmed/27909050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745208
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