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High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model
Major efforts are underway to identify agents that can potentiate effects of immune checkpoint inhibition. Here, we show that ascorbic acid (AA) treatment caused genomewide demethylation and enhanced expression of endogenous retroviral elements in lymphoma cells. AA also increased 5-hydroxymethylcyt...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983418/ https://ncbi.nlm.nih.gov/pubmed/31911474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908158117 |
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