Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

The Ten Eleven Translocation (TET) enzymes have been found to be mutated in both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting in DNA hypermethylation. Recent studies in embryonal stem cells showed that ascorbic acid (AA) is a cofactor for TET with a binding site at t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood Cancer J
Prif Awduron: Shenoy, N, Bhagat, T, Nieves, E, Stenson, M, Lawson, J, Choudhary, G S, Habermann, T, Nowakowski, G, Singh, R, Wu, X, Verma, A, Witzig, T E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549257/
https://ncbi.nlm.nih.gov/pubmed/28731456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2017.65
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