WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer

While multiple post-translational modifications have been reported to regulate the function of epidermal growth factor receptor (EGFR), the effect of protein methylation on its function has not been well characterized. In this study, we show that WHSC1L1 mono-methylates lysine 721 in the tyrosine ki...

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Udgivet i:Sci Rep
Main Authors: Saloura, Vassiliki, Vougiouklakis, Theodore, Zewde, Makda, Deng, Xiaolan, Kiyotani, Kazuma, Park, Jae-Hyun, Matsuo, Yo, Lingen, Mark, Suzuki, Takehiro, Dohmae, Naoshi, Hamamoto, Ryuji, Nakamura, Yusuke
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244396/
https://ncbi.nlm.nih.gov/pubmed/28102297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40664
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