WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck

Squamous cell carcinoma of the head and neck (SCCHN) is a malignancy with poor outcomes, thus novel therapies are urgently needed. We recently showed that WHSC1 is necessary for the viability of SCCHN cells through H3K36 di-methylation. Here, we report the identification of its novel substrate, hist...

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Publié dans:Neoplasia
Auteurs principaux: Saloura, Vassiliki, Vougiouklakis, Theodore, Bao, Riyue, Kim, Sohyoung, Baek, Songjoon, Zewde, Makda, Bernard, Benjamin, Burkitt, Kyunghee, Nigam, Nupur, Izumchenko, Evgeny, Dohmae, Naoshi, Hamamoto, Ryuji, Nakamura, Yusuke
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press 2020
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Original article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265065/
https://ncbi.nlm.nih.gov/pubmed/32497898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.05.002
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