Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds

Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the viral envelope glycoproteins (Env), a trimer of three gp120 exterior glycoproteins, and three gp41 transmembrane glycoproteins. The metastable Env is triggered to undergo entry-related conformational changes when gp120 b...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Madani, Navid, Princiotto, Amy M., Zhao, Connie, Jahanbakhshsefidi, Fatemeh, Mertens, Max, Herschhorn, Alon, Melillo, Bruno, Smith, Amos B., Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244334/
https://ncbi.nlm.nih.gov/pubmed/27881646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01880-16
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