Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer’s Disease

Interneurons, key regulators of hippocampal neuronal network excitability and synchronization, are lost in advanced stages of Alzheimer’s disease (AD). Given that network changes occur at early (presymptomatic) stages, we explored whether alterations of interneurons also occur before amyloid-beta (A...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Mahar, Ian, Albuquerque, Marilia Silva, Mondragon-Rodriguez, Siddhartha, Cavanagh, Chelsea, Davoli, Maria Antonietta, Chabot, Jean-Guy, Williams, Sylvain, Mechawar, Naguib, Quirion, Rémi, Krantic, Slavica
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243860/
https://ncbi.nlm.nih.gov/pubmed/28154533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2016.00327
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