IKBKE is required during KRAS-induced pancreatic tumorigenesis

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest malignancies lacking effective therapeutic strategies. Here we show that the non-canonical IκB-related kinase, IKBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation. Loss of IKBKE inhibits the initiation...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Rajurkar, Mihir, Dang, Kyvan, Fernandez-Barrena, Maite G., Liu, Xiangfan, Fernandez-Zapico, Martin E., Lewis, Brian C, Mao, Junhao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243176/
https://ncbi.nlm.nih.gov/pubmed/28069799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1684
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