PI3K Regulation of RAC1 is Required for KRAS-induced Pancreatic Tumorigenesis in Mice

BACKGROUND & AIMS: New drug targets are urgently needed for the treatment of pancreatic ductal adenocarcinoma (PDA). Nearly all PDAs contain oncogenic mutations in the KRAS gene. Pharmacologic inhibition of KRAS has been unsuccessful, leading to a focus on downstream effectors that are more easi...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Wu, Chia-Yen C., Carpenter, Eileen S., Takeuchi, Kenneth K., Halbrook, Christopher J., Peverley, Louise V., Bien, Harold, Hall, Jason C., DelGiorno, Kathleen E., Pal, Debjani, Song, Yan, Shi, Chanjuan, Lin, Richard Z., Crawford, Howard C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252806/
https://ncbi.nlm.nih.gov/pubmed/25311989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.032
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