The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis

Pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive human malignancies, is thought to be initiated by KRAS activation. Here we find that transcriptional activation mediated by the Gli family of transcription factors, although dispensable for pancreatic development, is required for Kr...

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Detalhes bibliográficos
Main Authors: Rajurkar, Mihir, De Jesus-Monge, Wilfredo E., Driscoll, David R., Appleman, Victoria A., Huang, He, Cotton, Jennifer L., Klimstra, David S., Zhu, Lihua J., Simin, Karl, Xu, Lan, McMahon, Andrew P., Lewis, Brian C., Mao, Junhao
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340052/
https://ncbi.nlm.nih.gov/pubmed/22493246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114168109
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