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Mitochondrial respiratory gene expression is suppressed in many cancers

The fundamental metabolic decision of a cell, the balance between respiration and fermentation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expression of the nuclear genome (nuDNA). Previously we described mtDNA copy number depletion across many solid tumor...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Reznik, Ed, Wang, Qingguo, La, Konnor, Schultz, Nikolaus, Sander, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243113/
https://ncbi.nlm.nih.gov/pubmed/28099114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21592
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