VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin‐directed AAA‐ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates to lysosomes and there c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Papadopoulos, Chrisovalantis, Kirchner, Philipp, Bug, Monika, Grum, Daniel, Koerver, Lisa, Schulze, Nina, Poehler, Robert, Dressler, Alina, Fengler, Sven, Arhzaouy, Khalid, Lux, Vanda, Ehrmann, Michael, Weihl, Conrad C, Meyer, Hemmo
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242375/
https://ncbi.nlm.nih.gov/pubmed/27753622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695148
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